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Because these processes occur gradually, changes in skin tone tend to be subtle and progressive

Apoptosis was detected using an Annexin V-FITC/PI Apoptosis Detection Kit

In order to elucidate in vivo mechanism of aldehyde-mediated tissue injury in ALDH2*2 carriers, here we investigate the pathology of Aldh2*2 knock-in (KI) mice with AA-induced acute exposure to acrolein, focusing on relationship between rapid systemic storm of reactive aldehydes and hepatocellular injury characterized by accumulation of aldehyde adducts

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